The association between glutamic acid decarboxylase antibody titre and incident diabetes

• Project/Area Number: 25893088
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hygiene and public health
• Research Institution: Fujita Health University (2014); Nagoya University (2013)
• Principal Investigator: LI Yuanying 藤田保健衛生大学, 医学部, 助教 (20701288)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: コホート研究 / 糖尿病 / 抗GAD抗体 / 保存血清 / 職域

Outline of Final Research Achievements

The Aichi workers’ cohort study is an ongoing study on cardiovascular diseases and diabetes among civil servants aged 35 to 66 years in Aichi Prefecture, located in central Japan. Baseline serum samples had been stored at -80 °C.
Serum antibodies to glutamic acid decarboxylase (GADA) titre were determined with AlphaLISA (amplified luminescence proximity homogeneous assay) method. Since significant variations in the absolute values existed between batches, GADA positive was defined as the highest decile in each batch. Of 2,846 subjects with valid GADA data as well as lifestyles and other potential confounders, 221 developed diabetes during approximately 10-year follow-up. Age- and sex-adjusted Cox regression analysis indicated a hazard ratio of 1.37 (95% confidence interval: 0.92-2.04). Further adjustment for menopausal status, smoking, exercise, body mass index, fasting blood glucose levels did not alter the association. We did not find association between GADA and risk of diabetes.

Research Products

• [Journal Article] Smoking and Diabetes: Is the Association Mediated by Adiponectin, Leptin, or C-reactive Protein? (2015)
  • Author(s): Hilawe EH, Yatsuya H, Li Y, Uemura M, Wang C, Chiang C, Toyoshima H, Tamakoshi K, Zhang Y, Kawazoe N, Aoyama A.
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 2 Pages: 99-109
  • DOI: 10.2188/jea.JE20140055
  • NAID: 130004704584
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Positive association between high sensitivity C-reactive protein and incidence of type-2 diabetes mellitus in Japanese workers : 6-year follow-up (2013)
  • Author(s): Wang C, Yatsuya H, Tamakoshi K, Uemura M, Li Y, Wada K, Yamashita K, Kawaguchi L, Toyoshima H, Aoyama A
  • Journal Title: Diabetes Metab Res Rev Volume: 29 Issue: 5 Pages: 398-405
  • DOI: 10.1002/dmrr.2406
  • Peer Reviewed