| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, the main metabolic pathways of synthetic cannabinoids, which sometimes cause acute intoxication cases, in rats and humans have been demonstrated. In both rats and humans, the main metabolic pathway of MAM-2201 is defluorination, followed by oxidation. In addition, postmortem redistribution of MAM2201, which may be due to its high lipophilicity, was observed in human cases. The determined metabolic pathways of MAM2201 in rats are almost similar to those in humans. Also, this study have revealed that slight modification in some moieties of synthetic cannabinoids causes different pharmacokinetic profile. Also, synthetic cannabinoids can cause endogenous metabolites in central nervous system and peripheral part, suggesting that it may be one of the causes of acute intoxication of synthetic cannabinoids.
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