Association of heart rate variability with silent cerebral lesions in a Japanese general population: a cross-sectional cohort study

• Project/Area Number: 25893097
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Epidemiology and preventive medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: HISAMATSU Takashi 滋賀医科大学, アジア疫学研究センター, 特任助教 (60710449)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 疫学 / 心拍変動 / 無症候性脳血管障害 / 24時間心電図

Outline of Final Research Achievements

Heart rate variability (HRV) reflects the autonomic nervous system. Little is known regarding the association of HRV with stroke risk in a general population. We conducted a cross-sectional study in a population-based sample of apparently healthy Japanese men to examine the association of nighttime (2 am to 2:15 am) and 24-hour HRV indices (SDNN, LF, HF, LF/HF ratio) quantified by 24-hour electrocardiogram with silent cerebral lesions (lacunar infarcts, microbleeds, white matter hyperintensities, brain artery stenoses) evaluated by brain magnetic resonance imaging. We found no significant associations between these HRV indices and silent cerebral lesions. In conclusion, in a community-based sample of Japanese men without clinical cardiovascular disease, HRV was not associated with silent cerebral lesions.

Research Products

• [Journal Article] High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men (2015)
  • Author(s): Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, For the SESSA Research group
  • Journal Title: Atherosclerosis Volume: 239 Issue: 2 Pages: 444-450
  • DOI: 10.1016/j.atherosclerosis.2015.01.031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population (2014)
  • Author(s): Takashi Hisamatsu、Akira Fujiyoshi、Katsuyuki Miura、Takayoshi Ohkubo、Aya Kadota、 Sayaka Kadowaki、Takashi Kadowaki、Takashi Yamamoto、Naoko Miyagawa、Maryam Zaid、Sayuki Torii、Naoyuki Takashima、Yoshitaka Murakami、Tomonori Okamura、Minoru Horie、Hirotsugu Ueshima; for the SESSA Research Group
  • Journal Title: Atherosclerosis Volume: 236 Issue: 2 Pages: 237-243
  • DOI: 10.1016/j.atherosclerosis.2014.07.019
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Association of Major and Minor ECG Abnormalities with Subclinical Atherosclerosis in a General Japanese Population: SESSA (2015)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Aya Kadota, Yasuyuki Nakamura, Minoru Horie, Hirotsugu Ueshima; for the SESSA Research Group
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Association of unrecognized myocardial infarction with silent cerebral lesions in elderly Japanese (2015)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Takayoshi Ohkubo, Akihiko Shiino, Kazuhiko Nozaki, Sayuki Torii, Sentaro Suzuki, Kiyoshi Murata, Hirotsugu Ueshima; for the SESSA Research Group
  • Organizer: 第40回日本脳卒中学会総会、STROKE2015
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] Modified LDL (Serum level of LOX-1 ligand containing ApoB) was associated with increased carotid intima-media thickness in Japanese community dwelling men especially with hypercholesterolemia. (2014)
  • Author(s): Tomonori Okamura, Tatsuya Sawamura, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naomi Miyamatsu, Katsuyuki Miura, and Hirotsugu Ueshima
  • Organizer: 9th World Stroke Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2014-10-22 – 2014-10-25
• [Remarks] 滋賀医科大学アジア疫学研究センター 研究紹介
  • URL: http://cera.shiga-med.ac.jp/project/index.html