| Project/Area Number |
25893097
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
HISAMATSU Takashi 滋賀医科大学, アジア疫学研究センター, 特任助教 (60710449)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 疫学 / 心拍変動 / 無症候性脳血管障害 / 24時間心電図 |
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| Outline of Final Research Achievements |
Heart rate variability (HRV) reflects the autonomic nervous system. Little is known regarding the association of HRV with stroke risk in a general population. We conducted a cross-sectional study in a population-based sample of apparently healthy Japanese men to examine the association of nighttime (2 am to 2:15 am) and 24-hour HRV indices (SDNN, LF, HF, LF/HF ratio) quantified by 24-hour electrocardiogram with silent cerebral lesions (lacunar infarcts, microbleeds, white matter hyperintensities, brain artery stenoses) evaluated by brain magnetic resonance imaging. We found no significant associations between these HRV indices and silent cerebral lesions. In conclusion, in a community-based sample of Japanese men without clinical cardiovascular disease, HRV was not associated with silent cerebral lesions.
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