Exploratory investigation of circadian clock mediated treatment of affective disorder

• Project/Area Number: 25893099
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: MATSUO Masahiro 滋賀医科大学, 医学部, 講師 (70456838)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 気分障害 / 時計遺伝子 / 時間治療学 / 睡眠覚醒リズム

Outline of Final Research Achievements

Affective disorders, including depression, are reported to affect as much as 3% of general population. Although affective disorders are quite common disease nowadays, pharmacotherapy that is used most often used to treat the disease, requires more than 2 weeks to induce first improving effects on the disease.
In contrary to conventional pharmacotherapy, interventions focusing on the sleep/wake cycle are used if not common as pharmacotherapy. These include sleep deprivation therapy, light therapy, and they are known to improve disease faster than 2 weeks.
In this study, we focused on the anti-depression mechanism of these sleep/wake cycle mediated depression therapy. By examining the molecular mechanisms of therapeutic effects and their time-dependency, it is expected to pave the way to develop more sophisticated therapy of depression.

Research Products

• [Journal Article] A Cross-sectional Study on Working Hours, Sleep Duration and Depressive Symptoms in Japanese Shift Workers. (2015)
  • Author(s): Hiroshi Kadotani, Nakada Y, Murakami J, Matsuo M, Itou H, Yamada N
  • Journal Title: Journal of Oral Sleep Medicine Volume: 1 Pages: 2-2
  • NAID: 130007770859
  • Peer Reviewed
• [Journal Article] Association of sleep-disordered breathing with decreased cognitive function among patients with dementia (2014)
  • Author(s): Kiyoaki Aoki, Masahiro Matsuo, Masahiro Takahashi, Junichi Murakami, Yasusuke Aoki, Naosuke Aoki, Hirotaka Mizumoto, Ayako Namikawa, Hiroko Hara, Masaharu Miyagawa, Hiroshi Kadotani, Naoto Yamasa
  • Journal Title: Journal of Sleep Research Volume: 6 Issue: 5 Pages: 517-517
  • DOI: 10.1111/jsr.12167
  • Peer Reviewed
• [Journal Article] MSLTにおけるクラスタリング分類と,主観的眠気と睡眠潜時の関連について (2014)
  • Author(s): 鷹見将規、松松尾 雅博, 今井 眞, 加根村 隆, 中林 孝夫, 泉尾 護, 角谷 寛, 山田 尚登
  • Journal Title: 不眠研究 Volume: 2014 Pages: 33-37
  • Peer Reviewed
• [Presentation] Association of sleep-disordered breathing with decreased cognitive function in dementia patients. (2014)
  • Author(s): Masahiro Matsuo, Kiyoaki Aoki, Masahiro Takahashi, Junichi Murakami, Hiroshi Kadotani, Naoto Yamada
  • Organizer: Asia Sleep Research Society Conference
  • Place of Presentation: Uday Samudra, Kovalam
  • Year and Date: 2014-09-22 – 2014-09-24
• [Presentation] アクチウォッチを用いた行動と光環境の同調性の個体差の検討 (2014)
  • Author(s): 松尾雅博、角谷寛、鷹見将規、今井眞、山田尚登
  • Organizer: 日本睡眠学会 第39回定期学術集会
  • Place of Presentation: あわぎんホール
  • Year and Date: 2014-07-03 – 2014-07-04
• [Presentation] 認知症における認知機能の低下と呼吸関連睡眠障害の関連 (2014)
  • Author(s): 山田尚登, 松尾雅博, 高橋正洋, 村上純一, 青木浄亮, 青木泰亮, 青木直亮, 水元洋貴, 並川綾子, 原宏子, 宮川正治, 角谷寛
  • Organizer: 日本睡眠学会 第39回定期学術集会
  • Place of Presentation: あわぎんホール
  • Year and Date: 2014-07-03 – 2014-07-04
• [Presentation] 主観的な眠気と客観的な眠気の関連について (2014)
  • Author(s): 鷹見将規、今井眞、松尾雅博、加根村隆、山本彬、中林孝夫、泉尾護、角谷寛、山田尚登
  • Organizer: 日本睡眠学会 第39回定期学術集会
  • Place of Presentation: あわぎんホール
  • Year and Date: 2014-07-03 – 2014-07-04