| Project/Area Number |
25893099
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 気分障害 / 時計遺伝子 / 時間治療学 / 睡眠覚醒リズム |
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| Outline of Final Research Achievements |
Affective disorders, including depression, are reported to affect as much as 3% of general population. Although affective disorders are quite common disease nowadays, pharmacotherapy that is used most often used to treat the disease, requires more than 2 weeks to induce first improving effects on the disease.
In contrary to conventional pharmacotherapy, interventions focusing on the sleep/wake cycle are used if not common as pharmacotherapy. These include sleep deprivation therapy, light therapy, and they are known to improve disease faster than 2 weeks.
In this study, we focused on the anti-depression mechanism of these sleep/wake cycle mediated depression therapy. By examining the molecular mechanisms of therapeutic effects and their time-dependency, it is expected to pave the way to develop more sophisticated therapy of depression.
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