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Perfusion CT to evaluate pancreatic stroma in pancreatic cancer mice model

Research Project

Project/Area Number 25893105
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

TSUJI Yoshihisa  京都大学, 医学(系)研究科(研究院), その他 (10711541)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsPerfusion CT / 膵 / 膵癌 / 線維化 / 膵線維化
Outline of Final Research Achievements

In the present study, a significantly strong correlation was found between the imaging parameter (Fis) of perfusion CT, which targeted the contrast accumulation in the intstitial space and relects tumor-associated stroma in this model, and stromal density quantified using immunohistochemistry; this finding supported our hypothesis that perfusion CT had the potential to depict a similar spatial distribution of tumor-associated stroma to that confirmed using histopathological analysis. In terms of the association between tumor hypoxia and tumor-associated stroma, FMISO uptake had a negative correlation with Fis and stromal density, as well as with vascular parameters. These results suggest that tumor hypoxia was complementarily localized to tumor-associated stroma and the vascular component.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 4 results) Book (2 results)

  • [Journal Article] Perfusion in the tissue surrounding pancreatic cancer and the patient’s prognosis.2014

    • Author(s)
      Nishikawa Y, Tsuji Y, Isoda H, Kodama Y, Chiba T.
    • Journal Title

      Journal of Biomed Res Int.

      Volume: 1 Pages: 1-6

    • DOI

      10.1155/2014/648021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subtraction color-map of contrast-enhanced and unenhanced CT for prediction of pancreatic necrosis in early stage of acute pancreatitis2014

    • Author(s)
      Tsuji Yoshihisa, Takahashi Noki, Joel G. Fletcher
    • Journal Title

      American Journal of Radiology

      Volume: 202 Issue: 4 Pages: 349-356

    • DOI

      10.2214/ajr.13.10957

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 急性膵炎の診断と治療:新しい動向-血流から見た急性膵炎の初期病態: Perfusion CTによる検討.2014

    • Author(s)
      辻喜久、児玉裕三、千葉勉.
    • Journal Title

      膵臓

      Volume: In press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Use and Importance of Intra-arterial Protease Inhibitor Treatment.2014

    • Author(s)
      Tsuji Y.
    • Organizer
      APA, Symposium
    • Place of Presentation
      Hawaii
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Perfusion CT/MRI and their applications to pancreatic and hepatic diseases.

    • Author(s)
      Tsuji Yoshihisa
    • Organizer
      MICCAI 2013, keynote lecture
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pancreatic perfusion image; the current and future

    • Author(s)
      Tsuji Yoshihisa
    • Organizer
      AIMS, Lecture
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 膵perfusion CTの現状と今後

    • Author(s)
      辻 喜久
    • Organizer
      第33回日本画像医学会 ランチョンセミナー
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Pancreatic blood flow measurements in the pig pancreatitis model using perfusion CT with deconvolution method. Abdominal Imaging - Computational and Clinical Applications.2014

    • Author(s)
      Tsuji Y, Yamada K, Kisimoto M, Yazumi S, Isoda H, Chiba T.
    • Total Pages
      6
    • Publisher
      Springer, NY in press
    • Related Report
      2014 Annual Research Report
  • [Book] Computed Tomography New Research, Chapter 3; Technique and clinical applications of hepatic perfusion CT with dual-input algorithms2013

    • Author(s)
      Koyasu Sho, Tsuji Yoshihisa
    • Total Pages
      550
    • Publisher
      Nova Publishers, NY
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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