Perfusion CT to evaluate pancreatic stroma in pancreatic cancer mice model
| Project/Area Number |
25893105
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUJI Yoshihisa 京都大学, 医学(系)研究科(研究院), その他 (10711541)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Perfusion CT / 膵 / 膵癌 / 線維化 / 膵線維化 |
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| Outline of Final Research Achievements |
In the present study, a significantly strong correlation was found between the imaging parameter (Fis) of perfusion CT, which targeted the contrast accumulation in the intstitial space and relects tumor-associated stroma in this model, and stromal density quantified using immunohistochemistry; this finding supported our hypothesis that perfusion CT had the potential to depict a similar spatial distribution of tumor-associated stroma to that confirmed using histopathological analysis. In terms of the association between tumor hypoxia and tumor-associated stroma, FMISO uptake had a negative correlation with Fis and stromal density, as well as with vascular parameters. These results suggest that tumor hypoxia was complementarily localized to tumor-associated stroma and the vascular component.
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Report
(3 results)
Research Products
(9 results)
