| Project/Area Number |
25893109
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 分子イメージング / 放射性医薬品 / SPECT / アルツハイマー病 |
|---|
| Outline of Final Research Achievements |
The deposition of β-amyloid (Aβ) peptides in the brain is a well-established biomarker of Alzheimer’s disease (AD). Since the deposition of Aβ plaques is considered to be the initial neurodegenerative event in AD, Aβ is the major target of early diagnosis and treatment for AD. In this study, we planned the development of novel probes labeled with technetium-99m (Tc-99m). Tc-99m has become the most commonly used radionuclide in diagnostic nuclear medicine. PQ-C3-BAT and 1,3,4-DPOD-2P-BAT which were developed in this study showed high affinity for Aβ aggregates in vitro. In addition, these probes showed initial uptake into and rapid clearance from the normal mouse brain. These results suggested that PQ-C3-BAT and 1,3,4-DPOD-2P-BAT may be potential probes for imaging Aβ plaques in AD brains.
|
