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Development of novel 99mTc labeled amyloid imaging probes for diagnosis of Alzheimer's disease

Research Project

Project/Area Number 25893109
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

WATANABE Hiroyuki  京都大学, 薬学研究科(研究院), 助教 (40710786)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords分子イメージング / 放射性医薬品 / SPECT / アルツハイマー病
Outline of Final Research Achievements

The deposition of β-amyloid (Aβ) peptides in the brain is a well-established biomarker of Alzheimer’s disease (AD). Since the deposition of Aβ plaques is considered to be the initial neurodegenerative event in AD, Aβ is the major target of early diagnosis and treatment for AD. In this study, we planned the development of novel probes labeled with technetium-99m (Tc-99m). Tc-99m has become the most commonly used radionuclide in diagnostic nuclear medicine. PQ-C3-BAT and 1,3,4-DPOD-2P-BAT which were developed in this study showed high affinity for Aβ aggregates in vitro. In addition, these probes showed initial uptake into and rapid clearance from the normal mouse brain. These results suggested that PQ-C3-BAT and 1,3,4-DPOD-2P-BAT may be potential probes for imaging Aβ plaques in AD brains.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Synthesis and Biological Evaluation of 123I-Labeled Pyridyl Benzoxazole Derivatives: Novel β-Amyloid Imaging Probes for Single-Photon Emission Computed Tomography.2015

    • Author(s)
      Watanabe H, Ono M, Iikuni S, Okamoto Y, Ihara M, Takahashi R, Saji H.
    • Journal Title

      RSC Adv.

      Volume: 5 Issue: 2 Pages: 1009-1015

    • DOI

      10.1039/c4ra10742j

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Novel PET/SPECT Probes for Imaging of Tau in Alzheimer’s Disease.2015

    • Author(s)
      Watanabe H, Ono M, Saji H.
    • Journal Title

      ScientificWorldJournal

      Volume: 2015 Issue: 1 Pages: 124192-124192

    • DOI

      10.1155/2015/124192

    • NAID

      120005666203

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 68Ga complex based on benzofuran scaffold for the detection of β-amyloid plaques.2014

    • Author(s)
      Watanabe H, Ono M, Iikuni S, Yoshimura M, Matsumura K, Kimura H, Saji H.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 20 Pages: 4834-4837

    • DOI

      10.1016/j.bmcl.2014.08.058

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Novel Radioiodinated 1,3,4-Oxadiazole Derivatives with Improved in Vivo Properties for SPECT Imaging of β-Amyloid Plaques2014

    • Author(s)
      Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Kenji Matsumura, Masashi Yoshimura, Shimpei Iikuni, Yoko Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hideo Saji
    • Journal Title

      Medicinal Chemistry Communications

      Volume: 5 Issue: 1 Pages: 82-85

    • DOI

      10.1039/c3md00189j

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] β-アミロイドおよびタウの生体イメージングを目的としたSPECTプローブの開発2014

    • Author(s)
      渡邊 裕之, 小野 正博, 木村 寛之, 佐治 英郎
    • Organizer
      第54回日本核医学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular imaging of β-amyloid plaques in Alzheimer’s disease with single photon emission computed tomography2014

    • Author(s)
      Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Hideo Saji.
    • Organizer
      The 37th NAITO CONFERENCE
    • Place of Presentation
      ヒルトンニセコビレッジ
    • Year and Date
      2014-07-15 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピリジルベンゾオキサゾールを母核としたSPECT用βアミロイドイメージングプローブの開発2013

    • Author(s)
      渡邊裕之、小野正博、飯國慎平、木村寛之、佐治英郎
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学大学院薬学研究科・病態機能分析学分野

    • URL

      http://www.pharm.kyoto-u.ac.jp/byotai/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

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