Expression control mechanism and function of immunosuppressive molecule PD-L1 in ovarian cancer
| Project/Area Number |
25893112
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
ABIKO Kaoru 京都大学, 医学(系)研究科(研究院), 助教 (20508246)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 卵巣癌 / 免疫 / PD-L1 / リンパ球 / インターフェロンガンマ / 腹膜播種 / インターフェロンγ / NF-kB |
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| Outline of Final Research Achievements |
In ovarian cancer clinical samples, the number of CD8-positive cells in cancer stroma was strongly correlated to PD-L1 expression on the tumor cells. In mouse models, depleting IFNGR1 resulted in lower level of PD-L1 expression in tumor cells, increased number of tumor-infiltrating lymphocytes, inhibition of tumor growth, and longer survival.
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Report
(3 results)
Research Products
(10 results)
