The roles of cyclic adenosine monophosphate (cAMP) in suppressive functions of regulatory T cells

Research Project

Project/Area Number	25893115
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Immunology
Research Institution	Osaka University
Principal Investigator	MIKAMI Norihisa 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (20710388)
Project Period (FY)	2013-08-30 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	制御性T細胞 / cAMP / 免疫学
Outline of Final Research Achievements	As results of the analysis of the effect on regulatory T cells of cAMP signaling, we demonstrated that it contributes to the Helios stability and IL-2 expression in regulatory T cells. Moreover, cAMP signal is induced to effector T cells by regulatory T cells, whereby it was shown that IL-2 production from effector T cells is also inhibited. Furthermore, it becomes clear that dendritic cells are also affected by regulatory T cells occurs, and the production of inflammatory cytokines such as IL-12 were also decreased by induced cAMP signaling.