The pathophysiology of rheumatoid arthritis elucidated by intravital multiphoton imaging
Project/Area Number |
25893117
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Osaka University |
Principal Investigator |
KIKUTA Junichi 大阪大学, 医学(系)研究科(研究院), 助教 (60710069)
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Project Period (FY) |
2013-08-30 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 関節リウマチ / 生体イメージング / 破骨細胞 |
Outline of Final Research Achievements |
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial joint inflammation and progressive cartilage/bone destruction. Arthritic bone destruction is considered to be mediated mainly by enhanced activation of osteoclasts at inflammatory sites. In this study, I established the advanced imaging system to visualize the cellular dynamics in arthritic joints with intravital multiphoton microscopy. By means of this system, I succeeded in visualization of abnormally activated osteoclasts in arthritic inflammation and bone destruction. Furthermore I revealed the in vivo effects of biologic agents on osteoclast function. This imaging approach would be beneficial for studying the pathophysiology of RA in vivo and would thus be useful for evaluating novel anti-rheumatic drugs.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.2015
Author(s)
Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M.
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Journal Title
The Journal of Biological Chemistry
Volume: 290
Pages: 6326-6337
DOI
Related Report
Peer Reviewed
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[Journal Article] Interferon-α Acts on the S/G2/M Phases to Induce Apoptosis in the G1 Phase of an IFNAR2-Expressing Hepatocellular Carcinoma Cell Line.2014
Author(s)
Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, Naito A, Kikuta J, Ishii T, Tomimaru Y, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Umeshita K, Ishii H, Doki Y, Mori M, Ishii M.
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Journal Title
The Journal of Biological Chemistry
Volume: 289
Pages: 23786-23795
DOI
Related Report
Peer Reviewed
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[Journal Article] Generation of colonic IgA-secreting cells in the caecal patch.2014
Author(s)
Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K.
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Journal Title
Nature Communications
Volume: 5
Pages: 3704
DOI
Related Report
Peer Reviewed
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[Journal Article] Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo.2013
Author(s)
Kagawa Y, Matsumoto S, Kamioka Y, Mimori K, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M.
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Journal Title
PLoS One
Volume: 8
Pages: e83629
DOI
Related Report
Peer Reviewed
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