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The comtribution of complement regularoty factor, CD46, during T cell mediated rejection in kidney allograft

Research Project

Project/Area Number 25893119
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

KAKUTA Yoichi  大阪大学, 医学(系)研究科(研究院), 助教 (40710116)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords腎移植 / 拒絶反応 / 補体 / 補体制御因子 / 急性拒絶反応 / CD46
Outline of Final Research Achievements

The complement system plays a critical role in both innate and adaptive immune responses. We found locally produced complement component 3 (C3) from renal allografts and downregulation of complement regulatory factor(CRF) activated the complement system during acute cellular rejection in animal models. When anti-CRF antibody was injected, acute cellular rejection was promoted. Moreover, We demonstrated that CD46 expression in human renal tubular cells during acute cellular rejection may influence the outcome of treatment and graft survival. Grafts from older donors may be a risk factor for decreased expression of CD46 in renal tubular cells. The clinical application of complement regulatory protein including CD46 and complement regulatory drugs is considered to have some potential for suppressing acute cellular rejection after transplantation and to improve graft outcome.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (3 results)

All 2015 2014 2013

All Presentation (3 results)

  • [Presentation] Depression of complement regulatory factors in human and rat renal grafts in association with progress of acute cellular rejection2015

    • Author(s)
      Kazuaki Yamanaka
    • Organizer
      アメリカ移植学会
    • Place of Presentation
      アメリカ(フィラデルフィア)
    • Year and Date
      2015-05-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 移植腎における補体制御因子CD46の発現が予後に与える影響2014

    • Author(s)
      角田洋一
    • Organizer
      第79回日本泌尿器科学会東部総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2014-10-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 移植腎における補体制御因子CD46の発現が予後に与える影響2013

    • Author(s)
      角田 洋一
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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