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Elucidation of the central control mechanism of salivation for establishment of new therapy of xerostomia

Research Project

Project/Area Number 25893139
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOkayama University

Principal Investigator

MAEDA Naoto  岡山大学, 医歯(薬)学総合研究科, 助教 (10708051)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords唾液分泌 / 大脳皮質咀嚼野 / 顎運動 / 筋電図 / ラット
Outline of Final Research Achievements

The purpose of this study is to clarify the relationship between jaw movement and salivary secretion occurring upon electrical stimulation two cortical masticatory areas in rats.
In this study, jaw movement and submandibular salivary secretion were recorded at the same time when two different cortical masticatory areas (A-area, P-area) were stimulated electrically. As a result, it became clear that P-area stimulation induced vigorous salivary secretion and rhythmical jaw movements resembling masticatory movements. In addition, salivary flow persisted even after minimizing jaw movements by curarization. From these, salivary secretion not only occur reflexively by oral sensation caused by jaw movement, it became clear that it is also controlled to the central.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (4 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Effect of nasal speaking valve on speech intelligibility under velopharyngeal incompetence: a questionnaire survey.2015

    • Author(s)
      Shin Mikamo, Naoki Kodama, Qiuyue Pan, Naoto Maeda, Shogo Minagi
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 42 Issue: 2 Pages: 136-143

    • DOI

      10.1111/joor.12237

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential involvement of two cortical masticatory areas in submandibular salivary secretion in rats.2014

    • Author(s)
      Maeda N, Kobashi M, Mitoh Y, Fujita M, Minagi S, Matsuo R
    • Journal Title

      Brain Res

      Volume: 1543 Pages: 200-208

    • DOI

      10.1016/j.brainres.2013.11.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 舌根相当部頸部表面電極を用いた筋電図の基礎特性2014

    • Author(s)
      萬田陽介,前田直人,福池知穂,潘秋月,杉本恭子,橋本有希,皆木省吾
    • Organizer
      第20回日本摂食嚥下リハビリテーション学会
    • Place of Presentation
      京王プラザホテル 東京
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唾液分泌における大脳皮質咀嚼野の役割2013

    • Author(s)
      前田直人,松尾龍二
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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