Elucidation of mechanism of antibody-related rejection bay using humanized immunodeficient mice lacking xenogeneic antigen

Research Project

Project/Area Number	25893143
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Hiroshima University
Principal Investigator	TAHARA HIROYUKI 広島大学, 大学病院, 医科診療医 (30423354)
Project Period (FY)	2013-08-30 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	移植免疫 / 移植・再生医療 / トランスレーショナルリサーチ / 免疫学 / 糖鎖 / 異種移植
Outline of Final Research Achievements	We aim to elucidate mechanism of antibody-mediated rejection in xenogeneic or allogeneic transplantation and develop the therapy in order to overcome chronic antibody-related rejection which is the most important issue in transplantation. We are now approaching establishment of the humanized mouse model during this period (①severe immunodeficient mice lacking Gal and NeuGc Ag, ②severe immunodeficient mice having human immune cells)