Elucidation of mechanism of antibody-related rejection bay using humanized immunodeficient mice lacking xenogeneic antigen
| Project/Area Number |
25893143
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 移植免疫 / 移植・再生医療 / トランスレーショナルリサーチ / 免疫学 / 糖鎖 / 異種移植 |
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| Outline of Final Research Achievements |
We aim to elucidate mechanism of antibody-mediated rejection in xenogeneic or allogeneic transplantation and develop the therapy in order to overcome chronic antibody-related rejection which is the most important issue in transplantation. We are now approaching establishment of the humanized mouse model during this period (①severe immunodeficient mice lacking Gal and NeuGc Ag, ②severe immunodeficient mice having human immune cells)
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Report
(3 results)
Research Products
(3 results)
