| Project/Area Number |
25893147
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YOSHIMI Yuki 広島大学, 大学病院, 歯科診療医 (50707081)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アメロゲニン / 歯根吸収 / ペプチド / セメント芽細胞 |
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| Outline of Final Research Achievements |
Amelogenin is a major enamel matrix protein produced by ameloblasts. EMP plays a crucial role in periodontal tissue generation as well as amelogenesis. The purpose of this study was to explore bioactive domain of amelogenin, by examining the effect of several fragments of amelogenin on cementblasts and odontclast, to reveal signal pathway of amelogenin, and to develop a new therapeutic method for prevent of root resorption with orthodontic treatment. It is shown that C-terminal of amelogenin peptide enhance the proliferation and differntiation of cementblasts, and C-terminal peptide of amelogenin enhance the proliferation of cementblast via MAPK-ERK pathway.It is thus suggested that C-terminal peptide of full-length amelogenin is a bioactive domein of amelogenin, and C-terminal peptide of amelogenin is effective to promote cellular activity of cementblast.
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