| Project/Area Number |
25893153
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
WATANABE Kenji 山口大学, 大学研究推進機構, 助教 (50711264)
|
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| Research Collaborator |
MIZUKAMI Yoichi
URUSHIMA Yutaka
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | TNBC / TAT protein |
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| Outline of Final Research Achievements |
Triple-negative breast cancer (TNBC) is one of breast cancer subtype and often shows more malignant phenotype compared to other subtype of breast cancer. Although there are many reports about TNBC, the master regulator involved in malignancy of TNBC is unclear. In this study, we paid our attentions to TNBC and tried to identify the master regulator involved in proliferation activity of TNBC. To achieve our purpose, we extracted the proteins from TNBC cell line, MDA-MB-231 cells, and fractionated them using ion-exchange chromatography. We transfected the each fractionated proteins into HCC38 cell by TAT system, and measured cell proliferation activity. However, the remarkable change was not detected.
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