| Project/Area Number |
25893159
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糖尿病 / 歯周病 / 小胞体ストレス / ATF6 / ノックアウトマウス |
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| Outline of Final Research Achievements |
Diabetes is a major risk factor for periodontal disease, which is an intraoral chronic inflammatory disease. The mechanisms that diabetes worsens periodontal disease involve immune dysfunction and abnormal collagen biosynthesis, are not completely understood. Recently, many studies have revealed the involvement of endoplasmic reticulum (ER) stress in various diseases. In this study, we have shown that activating transcription factor (ATF) 6 beta, one of three ER stress transducers, plays an important role in the activation of the macrophage. Further studies might open a new avenue for the treatment of periodontal disease through regulation of the immune system by the ER stress response signaling.
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