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DC-Dependent efficient prevention of spontaneous neuroblastoma in MYCN transgenic mice

Research Project

Project/Area Number 25893169
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

KAWAKUBO Naonori  九州大学, 大学病院, その他 (90711185)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経芽腫 / 腫瘍医学 / 小児外科学 / 免疫学
Outline of Final Research Achievements

Cultivation of lineage-negative hematopoietic progenitors from bone marrow of the mice of the same strain of MYCN transgenic mice in an optimized cytokine cocktail led to production of a large amount and high-purity dendritic cells.
Importantly, subcutaneous injection of the DCs pulsed with their tumor lysate almost completely prevents the tumor formation and much improved their survival in these mice. The depletion study of the effector cells suggested that the DC-therapy is dependent to CD4-positive cells.These results suggest that DC-based vaccine may possibly be a potential therapeutic to prevent neuroblastoma in clinical setting.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] DC-Dependent efficient prevention of spontaneous neuroblastoma in MYCN transgenic mice2015

    • Author(s)
      Naonori Kawakubo
    • Organizer
      2015 Keystone Symposia Conference C4: Dendritic Cells and Macrophages Reunited
    • Place of Presentation
      Fairmont The Queen Elizabeth, Montreal, QC, Canada
    • Year and Date
      2015-03-10
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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