Research Project
Grant-in-Aid for Research Activity Start-up
Cultivation of lineage-negative hematopoietic progenitors from bone marrow of the mice of the same strain of MYCN transgenic mice in an optimized cytokine cocktail led to production of a large amount and high-purity dendritic cells.Importantly, subcutaneous injection of the DCs pulsed with their tumor lysate almost completely prevents the tumor formation and much improved their survival in these mice. The depletion study of the effector cells suggested that the DC-therapy is dependent to CD4-positive cells.These results suggest that DC-based vaccine may possibly be a potential therapeutic to prevent neuroblastoma in clinical setting.
All 2015
All Presentation (1 results)
