| Project/Area Number |
25893173
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 炭酸アパタイト骨置換材 / 矯正力 / 生体吸収性 / 炭酸アパタイト / 骨置換材 |
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| Outline of Final Research Achievements |
For orthodontic treatment of teeth while bone defect exists in the jaw, reconstruction of the defect for tooth movement is necessary. In this study, reconstruction of the bone defect in animal model with carbonate apatite (CO3Ap) bone substitute was performed. Reaction of the teeth and bone substitute when orthodontic force was loaded on the surrounding teeth was evaluated histologically.
CO3Ap granules were implanted into the bone defect created on the palate side of the maxillary first molar of rat. After the healing period, the teeth were loaded with orthodontic force. It was confirmed that no excessive root resorption occurred on the teeth that had moved to the CO3Ap implant site. In addition, the CO3Ap that was in contact with the periodontal ligament had been adsorbed. Based on the result, it was suggested that tooth movement to the bone defect is possible by reconstruction with CO3Ap bone substitute.
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