| Project/Area Number |
25893182
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
KAWAI Yosuke (2014) 長崎大学, 病院(歯学系), 助教 (50423629)
河井 洋祐 (2013) 長崎大学, 大学病院, 助教 (80700236)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨芽細胞 / アポトーシス / BclxL / Bclxl / Bcl-xL |
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| Outline of Final Research Achievements |
In the present study, we generated conditional knockout mice with osteoblasts that express anti-apoptotic BCL-XL by using 2.3kb Col1a1 promoter Cre transgenic mice. In BCL-XL conditional knockout mice, apoptosis was increased in osteoblasts. Expression of BCL-XL in osteoblasts affected osteoclastogenesis. As a results, bone volume was decreased at 10 weeks of age because osteoclast formation was increased. These results show that BCL-XL may become the target for the osteoporosis treatment in the future.
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