Research Project
Grant-in-Aid for Research Activity Start-up
We conducted optogenetic stimulation in the hippocampus of anesthetized transgenic mice and confirmed that we could evaluate brain-wide responses using functional magnetic resonance imaging (fMRI) (Takata 2015). We constructed experimental system which can evaluate the brain response evoked by optogenetic stimulation in non-anesthetized mice and confirmed there are few motion artifacts. We found that there are significant differences in brain networks between anesthetized and non-anesthetized condition or before and after administration of serotonin enhancers using our novel system.We have collected the human resting-state fMRI data of patients with obsessive-compulsive disorder (OCD) to achieve the translational research of serotonergic system. Our preliminary results showed the possibility that we could discriminate OCD patients from healthy subjects especially using the brain networks though the striatum or frontal cortex consistent with our hypothesis.
All 2015 2014 Other
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (6 results) (of which Invited: 5 results)
PLoS One
Volume: 10 Issue: 3 Pages: e0121417-e0121417
10.1371/journal.pone.0121417
