Involvement of dendritic cells in the enhanced asthmatic immune responses in females
Project/Area Number |
25893222
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
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Project Period (FY) |
2013-08-30 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 気管支喘息 / 樹状細胞 / 性 / 性差 / ケモカイン / サイトカイン |
Outline of Final Research Achievements |
Gender-specific mortality rate in asthma is still female-preponderant. In the present study, we examined the role of dendritic cells (DCs) in the enhanced asthmatic immune responses in females using a mouse model. In WT mice, the allergic airway inflammation was significantly aggravated in females than in males. The expression levels of Ccl19, Ccl20, Il1b and Csf2 mRNA in the lung were significantly higher in female mice than in male mice. In line with these findings, the activated DC counts in the lung at 16 h after OVA inhalation were significantly greater in female mice than in male mice. These results suggest that DCs may contribute to the female predominance of Th2 immune responses in allergic asthma.
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Report
(3 results)
Research Products
(6 results)
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[Presentation] アレルギー性気道炎症におけるCD8+T細胞の関与2014
Author(s)
佐藤美希, 宮坂智充, 伊藤ちひろ, 奥山香織, 河野資, 大河原雄一, 菊地利明, 高柳元明, 大野勲
Organizer
第26回日本アレルギー学会春季臨床大会
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2014-05-09 – 2014-05-11
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[Presentation] 精神的ストレスによる免疫寛容の抑制と喘息発症2014
Author(s)
石垣貴裕, 河野資, 宮坂智充, 大河原雄一,高柳元明, 大野勲
Organizer
第54回呼吸器学会学術講演会
Place of Presentation
大阪国際会議場・リーガロイヤルホテル(大阪府大阪市)
Year and Date
2014-04-25 – 2014-04-27
Related Report