Elucidation of mitochondrial fission/fusion and mitophagy in Parkinson's disease

• Project/Area Number: 25893237
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Juntendo University
• Principal Investigator: KAWAJIRI Sumihiro 順天堂大学, 医学部, 助教 (30445522)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: パーキンソン病 / ミトコンドリア / 分裂

Outline of Final Research Achievements

I observed that mitochondrial fission was induced by VPS35 gene, one of Parkinson's disease (PD) causative gene, over-expression into human derived cultured cells using a fluorescence microscope live-imaging. However, I was not able to elucidate association between VPS35 and mitophagy. Based on these, I can consider that VPS35 regulates mitochondrial morphology and disruption of mitochondrial morphological regulation could lead to onset of PD

Research Products

• [Journal Article] Low dose of clonazepam is effective in the treatment of painless legs and moving toes syndrome: a case report. (2015)
  • Author(s): Kawajiri S, Noda K, Ikeda A, Koinuma T, Tomizawa Y, Hattori N, Okuma Y.
  • Journal Title: Case Reports in Neurology Volume: 7 Issue: 1 Pages: 59-62
  • DOI: 10.1159/000380942
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] p150 glued-associated disorders are caused by activation of intrinsic apoptotic pathway (2014)
  • Author(s): Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
  • Journal Title: PLoS One Volume: 9(4)
  • Peer Reviewed
• [Journal Article] Mutations in Fis1 disrupt orderly disposal of defective mitochondria (2014)
  • Author(s): Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM.
  • Journal Title: Molecular Biology of the Cell Volume: 25(1) Pages: 145-59
  • Peer Reviewed
• [Presentation] OMA1 regulates PINK1/Parkin pathway through Tim complex
  • Author(s): Kawajiri S, Yang H, Hattori N, and van der Bliek AM.
  • Organizer: International Symposium on Mitochondria 2013
  • Place of Presentation: 東京
• [Book] 神経疾患最新の治療2015-2017 (2014)
  • Author(s): 河尻澄宏、大熊泰之
  • Total Pages: 301
  • Publisher: 南江堂