Involvement of lipoprotein of periodontal ralated pathogens in evasion of phagocytosis.

• Project/Area Number: 25893244
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontology
• Research Institution: Showa University
• Principal Investigator: CHOU Kasei 昭和大学, 歯学部, 助教 (80710681)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 貪食 / 貪食受容体 / Streptococcus gordonii

Outline of Final Research Achievements

Periodontitis is chronic disease caused by bacteria. These periotondal pathogen must avoid host immuno defence like "Phagocytosis". It is important to established chronic infection.
In this study, we researched Streptococcus gordonii a periodontal related bacteria. S.gordonii have a protein PpiA, it plays an important role in inhibiting phagocytic engulfmet and in evasion of the host immune response. But, we did'nt know the mechanizm of inhibiting phagocytosis by PpiA protein. So, we exzamine the PpiA protein and macrophage cell menbrane protein interaction. The result showed that PpiA protein can conbined with 22kDa and 27kDa size cell menbrane protein. The protein may have one of the role to inhibition phagocytosis by PpiA.