Epigenetic alteration of Alzheimer disease candidate gene promoter region
| Project/Area Number |
25893251
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
SHINAGAWA Shunichiro 東京慈恵会医科大学, 精神医学講座, 助教 (90459628)
KOBAYASHI Nobuyuki 東京慈恵会医科大学, ウイルス学講座, 助教 (20385321)
YAMADA Hisashi 東京慈恵会医科大学, 総合医科学研究所, 教授 (20130213)
NAKAYAMA Kazuhiko 東京慈恵会医科大学, 精神医学講座, 教授 (70155878)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | アルツハイマー病 / エピジェティクス / 脳由来神経栄養因子 / DNAメチル化 / プロモーター / エピジェネティクス / メチル化 / 候補遺伝子 |
|---|
| Outline of Final Research Achievements |
The methylation levels of brain-derived neurotrophic factor (BDNF) gene
promoter region was significantly higher in the Alzheimer disaese (AD) patients than in the Normal Controls (NCs). Moreover, the methylation level was significantly and negatively correlated with some neuropsychological test subscores (registration, recall, and prehension behaviors scores). Therefore, such result implies that BDNF gene methylation levels reflecting neurocognitive function in AD patients may be useful as a surrogate marker to predict the clinical presentations or prognosis.
|
Report
(3 results)
Research Products
(8 results)
-
[Journal Article] Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease2015
Author(s)
Nagata T, Kobayashi N, Ishii J, Shinagawa S, Nakayama R, Shibata N, Kuerban B, Ohnuma T, Kondo K, Arai H, Yamada H, Nakayama K
-
Journal Title
Dement Geriatr Cogn Dis Extra
Volume: 5
Issue: 1
Pages: 64-73
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese2015
Author(s)
Kawai E, Shibata N, Nagata T, Shinagawa S, Tagai K, Ohnuma T, Shimazaki H, Toda A, Kasanuki K, Takayama T, Suzuki A, Nakayama K, Yamada H, Arai H.
-
Journal Title
Neuromolecular Med
Volume: 不詳
Related Report
Peer Reviewed
-
-
-
-
-
-
