| Project/Area Number |
25893259
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
TANAKA tomohiro 東京理科大学, 薬学部, ポストドクトラル研究員 (20711667)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 分子機械 / ロタキサン / バイオミメティック / 水溶性 / リン酸化酵素 / チオール / 酵素反応 / キラル分子 |
|---|
| Outline of Final Research Achievements |
In organism, various biomolecules was intricately interacted as machines and expressed its functions. A rotaxane is a mechanically-interlocked molecular architecture consisting of a dumbbell shaped molecule, which is threaded through a macrocycle. A series of rotaxanes, whose ring can be moved by external stimuli are called molecular shuttles, are attracting growing attention as basic structures of molecular machines. To date, most of the reported molecular machines function in organic solvents, and there are few example of water soluble molecular shuttle. Our interest is to design and synthesize bimolecular mimicry molecular shuttles.
In this work, we successfully synthesized a rotaxane that consists an axis having an azobenzen unit and Zn2+-cyclen station, and the a-CyD ring. NMR, UV-VIS, and CD experiments of this rotaxane and its derivatives having some functionalities on the ring such as kinase substrate and thiol.
|
