Molecular biological study of cells sheet derived from human dental follicle for bone regenerative medicine
| Project/Area Number |
25893263
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯嚢細胞 / 細胞シート / 骨再生 / 未分化間葉系幹細胞 / 石灰化能 / 歯嚢由来間葉系幹細胞 / 免疫組織化学染色 / 骨芽細胞分化 |
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| Outline of Final Research Achievements |
The dental follicle is an ectomesenchymally derived from the neural crest, which has connective tissue surrounding the tooth germ that contains stem cells and/or progenitor cells of the periodontium. Human dental follicle cells (hDFCs) have the ability to mineralize under in vitro culture using osteogenic induction medium. Cell sheet engineering is an emerging technology that is being researched for several tissue．This technique involves culturing cells to hyperconfluence and inducing matrix production for the formation of a robust tissue sheet. In this study, we investigate the abillity of cell che10516et derived from dental follicle cells for bone regeneration
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Report
(3 results)
Research Products
(5 results)
