| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Nighttime shift work-induced chronic jet lag caused increased cancer incidence and metabolic disorder. However, the effect of shift work on the circadian clock in the peripheral tissues was not well understood, because of the absence of the appropriate model of shift work. In the present study, we developed new model of shift work by changing light-dark cycle with forced awake to mice. We found deceased amplitude of circadian oscillation in the peripheral tissues in this model, and also forced awake caused stress accumulation and circadian resetting in the peripheral clocks. In addition, we developed liver specific circadian clock monitoring method in vivo using AAV.
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