Effect of night time shift work on the circadian clock system
| Project/Area Number |
25893265
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Waseda University |
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Principal Investigator |
TAHARA Yu 早稲田大学, 理工学術院, 助教 (80707399)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 体内時計 / 概日リズム / 交代勤務 |
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| Outline of Final Research Achievements |
Nighttime shift work-induced chronic jet lag caused increased cancer incidence and metabolic disorder. However, the effect of shift work on the circadian clock in the peripheral tissues was not well understood, because of the absence of the appropriate model of shift work. In the present study, we developed new model of shift work by changing light-dark cycle with forced awake to mice. We found deceased amplitude of circadian oscillation in the peripheral tissues in this model, and also forced awake caused stress accumulation and circadian resetting in the peripheral clocks. In addition, we developed liver specific circadian clock monitoring method in vivo using AAV.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Circadian regulation of allergic reactions by the mast cell clock in mice.2014
Author(s)
Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A
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Journal Title
J Allergy Clin Immunol
Volume: 133(2)
Issue: 2
Pages: 568-575
DOI
Related Report
Peer Reviewed
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