| Project/Area Number |
25893286
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Research Collaborator |
LEE Bok LEUL 釜山大学校, 薬学部, 教授
TAKAHASHI Kazue Harvard Medical School, Massachusetts General Hospital, Assistant Professor
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 細菌宿主相互作用 / 免疫賦活化 / 細胞壁タイコ酸 / 黄色ブドウ球菌 / 韓国：米国：ドイツ / 国際情報交換 / 韓国 / アメリカ合衆国 / ドイツ |
|---|
| Outline of Final Research Achievements |
Antibodies against wall teichoic acids (WTA) have major roles to protect against methicillin-resistant Staphylococcus aureus (MRSA) infection. Because WTA is well distributed among GC-low content Gram-positive bacteria, we hypothesize if anti-S. aureus WTA antibodies may be induced by non-pathogenic bacteria. Here, we found that a lactic acid producing bacterium belong to Lactobacillus species had an antigen recognized by anti-S. aureus WTA antibodies. This is a candidate non-pathogenic strain that may induce anti-MRSA antibodies.
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