| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Surgical valve replacement is an efficacious treatment for patients with cardiovascular disease, however the artificial heart valves have limitations regarding their durability. The in-body tissue architecture (IBTA) technology is a novel technique based on the tissue encapsulation phenomenon. Using this technology, autologous self-expanding valved stent, named Stent Biovalve, could be made simple and safe. However, the limited leaflet formation through the tissue migration was a serious problem. To solve this limitation, we have firstly established an effect on IBTA of the light radiation. Secondly, we evaluated directly and non-invasively the formation process of the leaflet tissues inside the mold. Moreover, we designed novel molds to activate leaflet formation. Finally, Stent Biovalve showed favorable hemodynamic results in pulmonary valve in beagles. Taken together, the novel method may improve a development of the functional Stent Biovalve.
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