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Organogenesis of nasopharynx- and tear duct-associated lymphoid tissues

Research Project

Project/Area Number 25893306
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Immunology
Research Institution独立行政法人医薬基盤研究所

Principal Investigator

NAGATAKE Takahiro  独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 (80608737)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords粘膜関連リンパ組織 / リンパ組織誘導細胞 / 組織形成 / 粘膜免疫
Outline of Final Research Achievements

CD3-CD4+CD45+ LTi cells plays a central role in mucosa-associated lymphoid tissues. In this study, we characterized and compared biological function of LTi cells in Peyer's patches (PPs), nasopharynx-associated lymphoid tissue (NALT) and tear duct-associated lymphoid tissue (TALT). It is found that PP-LTi cells expressed high amount of lymphotoxin which is essential for the genesis of PPs. In contrast, lymphotoxin was not expressed by NALT- and TALT-LTi cells. We also found that Cbfb2, a transcriptional regulator, was expressed in PPs-, NALT- and TALT-LTi cells. Cbfb2-deficient mice showed impairment of PPs-, NALT- and TALT-development. These results indicate that Cbfb2 is essential molecule for mucosa-associated lymphoid tissues.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (6 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Central role of core binding factor β2 in mucosa-associated lymphoid tissue organogenesis in mouse2015

    • Author(s)
      Takahiro Nagatake, Satoshi Fukuyama, Shintaro Sato, Hideaki Okura, Masashi Tachibana, Ichiro Taniuchi, Kosei Ito, Michiko Shimojou, Naomi Matsumoto, Hidehiko Suzuki, Jun Kunisawa, and Hiroshi Kiyono
    • Journal Title

      PLoS ONE

      Volume: 未定

    • NAID

      120006987038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine2014

    • Author(s)
      Nagatake T, Fujita H, Minato N, Hamazaki Y.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e90638-e90638

    • DOI

      10.1371/journal.pone.0090638

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique functions of mucosa-associated lymphoid tissues as targets of mucosal vaccines2013

    • Author(s)
      Takahiro Nagatake and Jun Kunisawa
    • Journal Title

      Current topics in pharmacology

      Volume: 17 Pages: 13-23

    • Related Report
      2013 Annual Research Report
  • [Presentation] Immunological and organogenesis diversity of mucosa-associated lymphoid tissues for the development of mucosal vaccine2015

    • Author(s)
      Takahiro Nagatake, Naomi Matsumoto, Michiko Shimojou, Hidehiko Suzuki, Satoshi Fukuyama, Shintaro Sato, Kentaro Ogami, Yusuke Tsujimura, Mitsuo Kawano, Tetsuya Nosaka, Hiroshi Kiyono, Yasuhiro Yasutomi, and Jun Kunisawa
    • Organizer
      第8回次世代アジュバント研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-01-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Eye immune responses initiated by uniquely developing tear duct-associated lymphoid tissue2013

    • Author(s)
      Takahiro Nagatake, Shintaro Sato, Jun Kunisawa and Hiroshi Kiyono
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Book] 医学のあゆみ-生命を支える脂質 最新の研究と臨床-(企画: 新井洋由)2014

    • Author(s)
      長竹貴広、國澤 純
    • Total Pages
      284
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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