| Project/Area Number |
25893306
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | 独立行政法人医薬基盤研究所 |
|---|
Principal Investigator |
NAGATAKE Takahiro 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 (80608737)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 粘膜関連リンパ組織 / リンパ組織誘導細胞 / 組織形成 / 粘膜免疫 |
|---|
| Outline of Final Research Achievements |
CD3-CD4+CD45+ LTi cells plays a central role in mucosa-associated lymphoid tissues. In this study, we characterized and compared biological function of LTi cells in Peyer's patches (PPs), nasopharynx-associated lymphoid tissue (NALT) and tear duct-associated lymphoid tissue (TALT). It is found that PP-LTi cells expressed high amount of lymphotoxin which is essential for the genesis of PPs. In contrast, lymphotoxin was not expressed by NALT- and TALT-LTi cells. We also found that Cbfb2, a transcriptional regulator, was expressed in PPs-, NALT- and TALT-LTi cells. Cbfb2-deficient mice showed impairment of PPs-, NALT- and TALT-development. These results indicate that Cbfb2 is essential molecule for mucosa-associated lymphoid tissues.
|
