Targeting sphingomyelin synthase inhibition for fatty liver disease control using paprika extracts

Research Project

Project/Area Number	25K00258
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 38050:Food sciences-related
Research Institution	Hokkaido University
Principal Investigator	BommeGowda SiddabasaveGowda 北海道大学, 保健科学研究院, 准教授 (50800504)
Co-Investigator(Kenkyū-buntansha)	惠淑萍北海道大学, 保健科学研究院, 教授 (90337030) DIVYAVANI 北海道大学, 保健科学研究院, 助教 (40875952)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2026: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	Paprika / obesity / Sphingolipid metabolism / lipids / LC/MS
Outline of Research at the Start	Spices are widely used in diets across the globe and are reported to have positive health benefits for obesity control. Our preliminary results revealed that paprika methanol extracts were found to inhibit both SMS1 and SMS2. Hence, this study aimed to identify and characterize the active metabolite of paprika inhibiting SMS1/SMS2 and reveal its biological action by in vitro and in vivo studies.