Reconstruction of the Thalamocortical Pathway in vitro to Model Neuropsychiatric Disorders

• Project/Area Number: 25K00283
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Koh IsabelSiewYin 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (90868415)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Brain organoid / Psychiatric disorder / Thalamocortical pathway

Outline of Research at the Start

Psychiatric disorders are difficult to study in humans for ethical reasons. This project aims to overcome this by generating iPSC models of different brain regions, and recapitulating their connection with each other to study how their function and interaction are affected in psychiatric disorders.