Design of Molecular Recognition Catalysts to Control Selectivity and Reactivity in Organic Synthesis

• Project/Area Number: 25K01777
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: イリエシュ ラウレアン 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームディレクター (40569951)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2027: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2026: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2025: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: organic synthesis / ligand design / selective catalysis / C-H activation

Outline of Research at the Start

Direct introduction of functionality into simple or complex molecules is of much interest, but in order to control reactivity and selectivity, typically specialized organic substrates must be used. This research aims at the development of a general strategy for the functionalization of a target C-H bond (and other strong bonds) in simple or complex arenes in an efficient and site-selective manner. This will be achieved through the design multifunctional ligands that recognize an organic substrate through noncovalent pi interactions.