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Modulation of the immune microenvironment by extracellular lipid metabolism

Research Project

Project/Area Number 25K02222
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 43030:Functional biochemistry-related
Research InstitutionThe University of Tokyo

Principal Investigator

武富 芳隆  東京大学, 大学院医学系研究科(医学部), 講師 (40365804)

Project Period (FY) 2025-04-01 – 2028-03-31
Project Status Granted (Fiscal Year 2025)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2027: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2026: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2025: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords脂質代謝 / リン脂質 / 生理活性脂質 / 免疫 / 疾患制御
Outline of Research at the Start

細胞外リン脂質の分解に関わる分泌性ホスホリパーゼA2 (sPLA2) 群のうち、構造がユニークなatypical sPLA2 (III, XIIA) の各欠損マウスが呈する免疫アレルギー疾患 (喘息、鼻炎、蕁麻疹、アトピー性皮膚炎、乾癬、関節炎) に関する表現型を基盤に、各sPLA2が動かす脂質代謝および当該疾患の制御機構の全体像を解明するとともに、atypical sPLA2の中和抗体や当該脂質シグナルの阻害/賦活化を免疫アレルギー疾患の予防治療に向けた新戦略として提唱することを目指す。

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Published: 2025-04-17   Modified: 2025-06-20  

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