動的分子内及び分子間相互作用を利用する新規ボロン酸誘導体の開発

• Project/Area Number: 25K02388
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related; Basic Section 47050:Environmental and natural pharmaceutical resources-related; Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: 井川 貴詞 岐阜薬科大学, 薬学部, 教授 (20453061)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2027: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2026: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2025: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: ボロン酸

Outline of Research at the Start

申請者は開発したArB(Epin) を含めた様々なボロン酸エステルの反応性と安定性を系統的に検討し、従来のボロン酸エステルの問題点を克服できると考えた。本申請研究では、分子内にホウ素官能基を持つ化合物を官能基選択的に化学変換して、従来法では合成困難な新規ボロン酸誘導体を合成する