Calix[4]arene-based molecular receptors: Strategy for selective binding of D-lactate and L-lactate, pathology and neurology related metabolites

• Project/Area Number: 25K08670
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 34010:Inorganic/coordination chemistry-related
• Research Institution: Kanazawa University
• Principal Investigator: IKBAL SK・ASIF 金沢大学, ナノ生命科学研究所, 特任助教 (50829463)
• Co-Investigator(Kenkyū-buntansha): 秋根 茂久 金沢大学, ナノ生命科学研究所, 教授 (30323265)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Metal complex / Lactate receptor / Calixarene / host-guest binding

Outline of Research at the Start

Fixing lactate encapsulated host-guest complexes orientation by DFT. Synthesis and characterizations of metallo-receptors using 1HNMR, 13C NMR, ESI-MS, and X-ray single crystal analysis.Lactate recognition and selectivity study using fluorescence spectra, CD spectra, ESI-MS.