Functional significance of surface molecules of senescence-associated extracellular vesicles in aging-induced immune deficiency

• Project/Area Number: 25K08934
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38030:Applied biochemistry-related
• Research Institution: Okinawa Institute of Science and Technology Graduate University
• Principal Investigator: RAZALI Nurhanani・Binti 沖縄科学技術大学院大学, 膜生物学ユニット, ポストドクトラルスカラー (70902667)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2025: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Senescence / Thymus biology / SASP

Outline of Research at the Start

The research purpose is to reveal the functional significance of intercellular signals between surface molecules of senescence-associated extracellular vesicles and immune cells. Hence, I will establish the in vivo senescence models using the aging-induced thymic involution. Senotherapeutics drugs targeting the senescence-associated extracellular vesicles can be the novel research particularly in aging populations in Japan, to slow aging and prevent age-related diseases.