Multiphase biomolecular condensation studied with large-scale molecular dynamics simulations

• Project/Area Number: 25K09590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 43040:Biophysics-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: 譚 丞 国立研究開発法人理化学研究所, 計算科学研究センター, 研究員 (20865886)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2025: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: biomolecular condensate / molecular dynamics

Outline of Research at the Start

This project uses advanced coarse-grained models and high-performance MD software GENESIS to study the formation and fusion dynamics of multiphase biomolecular condensates. Focusing on realistic systems, we aim to uncover physical principles underlying their organization and biological functions.