Investigation of the role of lysolipid-sensing receptor GPR55 in glia-to-neuron signaling in cerebellum development

• Project/Area Number: 25K09810
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Kyoto University
• Principal Investigator: GUY ADAM・TSUDA 京都大学, 生命科学研究科, 准教授 (30634779)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Lipid biology / Developmental biology / Neuroscience / GPCR / Cell biology

Outline of Research at the Start

This research will discover hitherto-undiscovered lipid-based mechanisms of cerebellar development. The signaling role of proteins in the cerebellum are well studied, but the concept of lipids acting as diffusible signaling molecules via activation of a specific GPCR is a new concept in the field of cerebellum research, and may help elucidate developmental mechanisms that hitherto remain unexplained by pure protein-based signaling.