Lipid hydroperoxide-induced insulin resistance through chemical modification: A novel molecular mechanism for type 2 diabetes

• Project/Area Number: 25K10042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Tohoku University
• Principal Investigator: 李 宣和 東北大学, 薬学研究科, 准教授 (60519776)
• Co-Investigator(Kenkyū-buntansha): 大江 知行 東北大学, 薬学研究科, 教授 (10203712) ; 幡川 祐資 東北大学, 薬学研究科, 助教 (30878351)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2027: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Lipid peroxidation / Chemical modification / Insulin resistance / Type 2 diabetes

Outline of Research at the Start

Type 2 diabetes is associated with oxidative stress, under which lipid hydroperoxides decompose to protein-reactive aldehydes. The proposed research will characterize lipid hydroperoxide-derived modifications to signaling proteins including insulin and investigate effects on insulin resistance.