Elucidation of protective effects of STB/HAP1 in neurodegenerative diseases by modulating gut-brain transneuronal transmission of their causal molecules

• Project/Area Number: 25K10145
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48010:Anatomy-related
• Research Institution: Yamaguchi University
• Principal Investigator: イスラム エムディノビウル 山口大学, 大学院医学系研究科, 講師 (80759671)
• Co-Investigator(Kenkyū-buntansha): 篠田 晃 名古屋学芸大学, ヒューマンケア学部, 教授 (40192108)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Neurodegeneration / Neuroprotection / HAP1 / Stigmoidbody

Outline of Research at the Start

We recently showed that huntingtin-associated protein 1 (HAP1), a neuroprotective interactor with the casual agents of NDs, is highly present in the ENS throughout the gut. In this study, we will examine the protective effects of STB/HAP1 against the gut-to-brain transmission of causal molecules of NDs using wild-type adult, wild-type-aged mice, HAP1-KO mice, and cultured cells.