Investigating Novel Mechanisms of Diastolic Dysfunction in Hypertrophic Cardiomyopathy

• Project/Area Number: 25K10174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48020:Physiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Waddingham Mark 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 (70822211)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2026: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: HCM / Myocardium / Sarcomere / Heat Shock Proteins / Diastolic Dysunction

Outline of Research at the Start

Patients with hypertrophic cardiomyopathy (HCM) often develop diastolic dysfunction, which is an inability for the heart to adequately relax. This diastolic dysfunction can lead to heart failure. In this project I will utilise a novel rat model of HCM to help better understand the mechanisms that drive diastolic dysfunction, in addition to testing a novel and rapidly translatable therapeutic strategy. It is hoped that this research project will enhance our understanding of diastolic dysfunction and ultimately prevent heart failure development in HCM.