Elucidation of the molecular mechanism of environmental stress response-mediated regulation of inflammation

• Project/Area Number: 25K10207
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48040:Medical biochemistry-related
• Research Institution: Tohoku University
• Principal Investigator: Baird Liam 東北大学, 未来型医療創成センター, 助教 (90724914)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Environmental stress

Outline of Research at the Start

Chronic inflammatory diseases, including heart disease and diabetes, are the most significant causes of death in the world. Understanding the mechanisms through which the NRF2-dependent stress response has anti-inflammatory effects will improve the therapeutic application of NRF2 inducers.