Investigation into the Clinical and Biological Significance of Monosomy 7 and del(7q) in Therapy-Related Myeloid Neoplasms

Research Project

Project/Area Number	25K10280
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 49020:Human pathology-related
Research Institution	University of Tsukuba
Principal Investigator	佐々木裕哉筑波大学, 附属病院, 病院講師 (50750725)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	急性骨髄性白血病 / 骨髄異形成症候群 / 治療関連骨髄性腫瘍
Outline of Research at the Start	Monosomy 7/del7qは治療関連骨髄異形成症候群 (MDS) や急性骨髄性白血病、小児 MDS で高頻度に認められる構造異常である。本研究では疾患の発症に深く関与する遺伝子を7q領域から同定し、機能解析研究を行うことで新規の治療方法の構築を目指す。