Activation off MAIT Cell in Francisella Infection: Mechanisms and Applications

Research Project

Project/Area Number	25K10361
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 49050:Bacteriology-related
Research Institution	Yamaguchi University
Principal Investigator	清水隆山口大学, 共同獣医学部, 准教授 (40320155)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2026: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	野兎病 / Francisella / MAIT細胞
Outline of Research at the Start	細菌の産生するリボフラビン合成経路中間産物5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU)は宿主のMucosal associated invariant T(MAIT)細胞を活性化し、生体防御に重要である。本研究ではMAIT細胞の活性化機構の詳細を明らかにすることにより、MAIT細胞を基盤としたワクチンやプロバイオティクス等の新たな細菌感染制御法の開発を目指す。