Brain drug screening research using a mass-produced human blood-brain barrier model

Research Project

Project/Area Number	25K10751
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52020:Neurology-related
Research Institution	Yamaguchi University
Principal Investigator	竹下幸男山口大学, 医学部, 教授(連携講座) (70749829)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2026: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	Blood-Brain Barrier
Outline of Research at the Start	1万個のcuBe kit (400 plate)を大量生産し、400種類の特許切れ薬剤ライブラリーを、血管内皮細胞側に作用させ、ペリサイト、アストロサイトでの神経栄養因子の分泌能を上昇させた化合物、かつ神経保護作用が確認できた化合物を標的化合物として同定する。