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Research on pathogenic immune cells associated with the gut-brain axis in neuroinflammation

Research Project

Project/Area Number 25K10802
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

木村 敦子  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 免疫研究部, 研究員 (60569143)

Project Period (FY) 2025-04-01 – 2028-03-31
Project Status Granted (Fiscal Year 2025)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsmultiple sclerosis / NKT cells / neuroinflammation
Outline of Research at the Start

Recent research indicates that the gut-brain axis (communication between CNS, intestines and microbiota) plays an important role in autoimmune diseases such as multiple sclerosis (MS). However, much remains unknown in this complex field. We have previously reported a therapeutic potential of targeting a subset of NKT cells, unconventional T cells that share properties of both T cells and NK cells. In this research, I aim to identify novel pathogenic immune cell populations potentially associated with the gut-brain axis in MS, using mouse models with a particular focus on NKT cells.

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Published: 2025-04-17   Modified: 2025-06-20  

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