肺高血圧症におけるSirt7の機能解析

• Project/Area Number: 25K11321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Kumamoto University
• Principal Investigator: 荒木 智 熊本大学, 病院, 特任教授 (20706717)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2025: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: Sirt7 / 肺高血圧

Outline of Research at the Start

本申請では肺高血圧症モデルにおけるSirt7の機能解析をin vivo、in vitroの両面から検証を行う。最終的にSirt7のターゲット因子を見出し、Sirt7による脱アセチル化部位の同定まで行う。