Investigation of mechanisms to avoid T cell exhaustion in inflammatory myopathies focusing on PD-1 expression regulation

• Project/Area Number: 25K11683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: Institute of Science Tokyo
• Principal Investigator: 佐々木 広和 東京科学大学, 東京科学大学病院, 助教 (30822639)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2026: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 特発性炎症性筋疾患

Outline of Research at the Start

IIMの疾患活動性等の臨床情報と符合した患者検体由来のデータセットを解析し、PD-1を含む免疫疲弊分子の発現制御に着目して、T細胞が持続的に活性化するメカニズムを明らかにする。