Comprehensive Understanding of Epigenomic Modifications in Thermogenic Adipocytes and Their Role in Improving Systemic Metabolism

Research Project

Project/Area Number	25K11787
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 54040:Metabolism and endocrinology-related
Research Institution	Hiroshima University
Principal Investigator	大野晴也広島大学, 病院(医), 講師 (60725894)
Project Period (FY)	2025-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2025)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2027: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	熱産生脂肪細胞 / エピゲノム
Outline of Research at the Start	過食や高温などの環境因子が熱産生脂肪細胞の機能に与える影響を調査し、エピゲノム修飾の変化を観察する。さらにはPPARαアゴニストの投与やMATIIα活性の制御を通じてエピゲノム修飾に介入し、熱産生脂肪細胞の機能を維持することで、全身の代謝機能を改善することを目指す。