development of technology to modify the cell membrane surface of human ES cell-derived cartilage for allogeneic transplantation

• Project/Area Number: 25K11879
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: The University of Tokyo
• Principal Investigator: 古村 眞 東京大学, 医学部附属病院, 特任教授 (10422289)
• Project Period (FY): 2025-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ES細胞 / 軟骨 / 気道再建

Outline of Research at the Start

ヒトES細胞移植は免疫拒絶反応を伴い、がん細胞はPD-L1分子でT細胞の免疫応答を抑制します。本研究はPD-L1を発現させる両親媒性高分子で細胞表面を改質し、同種三次元軟骨を再生することを目指します。方法はPD-L1発現条件の検討、改質後の評価、生体内評価、再生軟骨の機能評価です。